A collage of images featuring Bailey Laboratory activities.

Research

  • human TNBC cells expressing a GFP tagged protein
  • GFP expressing human TNBC liver metastasis
  • GFP expressing human TNBC brain metastasis
  • human TNBC xenograft primary tumors
Our goal is to understand the metastatic biology of triple negative breast cancer (TNBC) metastases. We ectopically express proteins tagged with green fluorescent proteins in TNBC cells to investigate their cellular localization and effect on stem cell formation in vitro.   In vivo investigation includes the use of a mouse human tumor xenograft model to visualize metastatic outgrowth and to ascertain whether the proteins promote the development of TNBC metastases. Techniques utilized include cell culture, lentiviral mediated transduction, flow cytometry, ELISA, immunoblot analysis, fluorescent confocal microscopy and stereomicroscopy, as well as subcutaneous and intracardiac injections of athymic mice.  

Research in our laboratory is supported by the University of Arkansas Chancellor’s Grant for Innovation and Collaboration, the University of Arkansas for Medical Sciences Arkansas Breast Cancer Program and The Arkansas Biosciences Institute.